T-cell leukemia with thymic involution
نویسندگان
چکیده
منابع مشابه
Thymic involution beyond T-cell insufficiency
It is well known that age-related involution (shrinkage) of the thymus (a central cellular immune organ) results in decreased output of naïve T cells [1]. The insufficiency of naïve T cells significantly reduces the T cell receptor repertoire diversity, thereby leading to immunosenescence. However, the deleterious effects of thymic involution extend beyond diminished output. It also increases t...
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Activated lymphocytes and lymphoid-tissue inducer cells express lymphotoxins (LTs), which are essential for the organogenesis and maintenance of lymphoreticular microenvironments. Here we describe that T-cell-restricted overexpression of LT induces fulminant thymic involution. This phenotype was prevented by ablation of the LT receptors tumor necrosis factor receptor (TNFR) 1 or LT beta recepto...
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In this review, we have summarized our work using combined complex statistical genetics, bioinformatics, and functional genomics to determine the genetic basis of the age-related thymic involution in C57BL/6J X DBA/2J recombinant inbred mice and the parental B6 and D2 mice. We have shown that these mice provided a valuable genetic model that can permit resampling of thymuses from different aged...
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A diverse array of T cells is required for defense against pathogens. The naive CD4 T-cell repertoire reaches its peak diversity by early human adulthood and is maintained until older age. Surprisingly, around age 70, this diversity appears to plummet abruptly. A similar qualitative pattern holds for the CD4 T memory-cell population. We used mathematical models to explore different hypotheses f...
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ژورنال
عنوان ژورنال: Cancer
سال: 1979
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(197902)43:2<622::aid-cncr2820430232>3.0.co;2-q